FrameWORX: Inside the Science That Sparked an Industry

Join BioCrossroads for FrameWORX screening of Cracking the Code: Phil Sharp and the Biotech Revolution. Set for release on October 6, this new documentary follows Phil (Phillip A.) Sharp, a Nobel Prize winning molecular biologist at MIT, whose discovery of RNA splicing in 1977 reshaped modern biology and helped lay the groundwork for today’s biotechnology. The film traces how a fundamental research insight moves from the lab to diagnostics and therapies that reach patients.

This event will include:

  • Opening remarks with context for Indiana’s life sciences community.
  • Feature film screening.
  • Post-film panel and audience Q&A.
  • Networking reception with peers and partners.

Event Details:
Wednesday, October 22, 2025
Doors open at 1:30 p.m. 
2 p.m. – 5 p.m. 
Roche – 9115 Hague Rd, Indianapolis, IN 46256
Building J/Forum

There is no cost to attend the FrameWORX screening on Oct. 22. 
Register early.  Seating is limited. 

Thank you to our hosts and presenting partners.

A Closer Look

 

Cracking the Code traces Phil Sharp’s path from rural Kentucky to the Nobel Prize and shows how the RNA splicing breakthrough shaped biotech and patient impact worldwide. Narrated by Mark Ruffalo. Directed by Bill Haney.

See the Trailer
 
 

 

Now an Official Heartland International Film Festival Selection

 


Cracking the Code: Phil Sharp and the Biotech Revolution has been officially selected to screen at the 2025 Heartland International Film Festival.


Public screenings will take place on Wednesday, October 15 at Living Room Theaters in Indianapolis and Saturday, October 18 at Alamo Drafthouse at The Square. Click the link below for more details about film festival tickets from HIFF.

Building Indiana’s Cancer Innovation Ecosystem

From groundbreaking research and clinical care to biomanufacturing and workforce development, this FrameWORX will showcase the full scope of Indiana’s capabilities in the fight against cancer. We’ll explore how cross-sector collaboration and strategic investment are fueling Indiana’s rise as a leader in cancer innovation, advancing prevention, diagnosis, treatment, and outcomes statewide.

Radiopharmaceuticals will be part of the conversation as well, highlighting how Indiana’s specialized manufacturing infrastructure, highly skilled talent, and unique logistics advantages are helping position our state as a national hub for cancer care and discovery.

Event Details

Date: Wednesday, March 12
Location: Indiana Biosciences Research Institute (IBRI), 16 Tech Innovation District, Indianapolis
Time: 3 p.m. – 5:30 p.m. 

FrameWORX: 

The Future of Musculoskeletal Health

Orthopedic Medicine and Indiana’s Leadership Opportunity

For more than two decades, BioCrossroads has played a central role in advancing Indiana’s life sciences sector, connecting key stakeholders, supporting strategic investments, and sharing the story of Indiana’s global leadership in innovation. In 2024, the state led the nation in life sciences exports, generating $99 billion in economic impact.

On August 20, we’ll convene our most ambitious FrameWORX yet in Warsaw, Indiana, recognized globally as the Orthopedic Capital of the World. ®

Up to 250 industry leaders, researchers, clinicians, and innovators will gather to explore the future of musculoskeletal health. Through insights from orthopedic surgeons, biomedical engineers, health economists, and patients, the event will highlight the scientific breakthroughs, clinical challenges, and economic implications shaping the next chapter of orthopedic medicine—and Indiana’s unique opportunity to lead it.

From chronic back pain and arthritis to advanced implants and surgical robotics, this discussion will spotlight the innovations redefining care and reaffirm Indiana’s leadership in one of healthcare’s most critical sectors.

Thank you to our sponsors

Agenda

1:00-1:05 PM
Welcome

Vince Wong, JD, MBA
President and CEO
BioCrossroads

1:05-1:25 PM
Warsaw: Leading the Way with Innovation

Drew Flamm - Moderator
President
Grace College

Ryan Christner
President and CEO
OrthoWorx


Emiko Kreklau, PhD
Executive Director, Catalyst Corridor
Grace College


Dr. Drew Flamm - Moderator
President
Grace College

1:25-1:50 PM

Keynote Address


Dr. Kurt Weiss
Professor
Pittsburgh Department of Orthopaedic Surgery
Division of Musculoskeletal Oncology

1:50-2:20 PM
The Perspective of Patients


Dr. Kurt Weiss
Professor
Pittsburgh Department of Orthopaedic Surgery
Division of Musculoskeletal Oncology

Patient Panelists

2:20-2:35 PM
Break
2:35-3:20 PM
Fireside Chat: Transformative Changes in Orthopedics



Hallie Brinkerhuff
Senior Director, R&D and Innovation
Zimmer Biomet



Roman Natoli, MD, PhD
Associate Professor
Indiana University Indianapolis



Dr. Kevin Otto
Dane A. Miller Head of the Weldon School of Biomedical Engineering
Purdue University




Jim Lancaster - Moderator
Orthopedics Executive
Leadership Team, All-IN Kosciusko

3:20-3:50 PM
Future of Manufacturing: Advanced Manufacturing and Workforce Development



Dr. Amrou Awaysheh
Professor and Endowed Chair
Indiana University Kelley School of Business



Laurent Ellenrieder
Manufacturing Director
Medartis USA


Brian Hodorek
President and CEO, Co-Founder
Ignite



Dr. Allyn Decker - Moderator
Vice President of Operations and Engagement
OrthoWorx

3:50-4:35 PM
Indiana's Opportunity for MSK Leadership



Melissa Kacena, PhD
Director, Indiana Center for MSK Health
Indiana University School of Medicine




Jim Lancaster
Orthopedics Executive
Leadership Team, All-IN Kosciusko



Brandon Noll
Director
Plug and Play Indiana



Rep. Craig Snow
Indiana State Representative, District 22



Ryan Christner - Moderator
President and CEO
OrthoWorx

4:35-4:55 PM
Final Thoughts



Hicham Drissi, PhD
Professor and Vice Chair of Research, Emory University School of Medicine
Director, Emory Musculoskeletal Research Center
President-Elect, Orthopaedic Research Society



Melissa Kacena, PhD
Director, Indiana Center for MSK Health
Indiana University School of Medicine


Dr. Kurt Weiss
Professor
Pittsburgh Department of Orthopaedic Surgery
Division of Musculoskeletal Oncology

4:55-5:00 PM

Closing Remarks



Vince Wong, JD, MBA
President and CEO
BioCrossroads

5:00-6:00 PM

Networking and Poster Session
MOCC, Grace College
Click the link below to learn more about our speakers. 
Frequently Asked Questions (FAQs)
How do I register for the tours?

To register for one of the two morning tours, please click here.

You may only select one tour, as the scheduled times overlap. 

Tour one runs from 9 a.m. until 11 a.m. 

Tour two runs from 10 a.m. until noon. 

Tours are limited to 25 participants each. Due to space limitations, if your plans change and you can no longer participate in your selected tour, please contact Barb Garringer at [email protected].

Please note, separate registration is required for the afternoon FrameWORX event at Grace College, which runs from 1 p.m. – 5 p.m., followed by a poster session. 

To register for the afternoon FrameWORX session only, click here to visit the EventBrite registration page. 

Separate paid registration is required for the ecosystem tours. 

There is no charge to attend the FrameWORX event. 

Separate paid registration is required for the ecosystem tours. Please see the previous FAQ. 

FrameWORX: June 12, 2025

Fueling our Future in Life Sciences and Healthcare Innovation

 

Join us for our next FrameWORX on June 12 at the Indiana Biosciences Research Institute, as we focus on building workforce resilience within in our life sciences ecosystem.

What You’ll Gain:
  • Actionable Insights: Learn how top organizations are successfully implementing internship programs, innovative apprenticeship models, and upskilling initiatives.
  • Real-Time Data: Explore current trends shaping recruitment, retention, and workforce expectations.
  • Networking Opportunities: Build meaningful connections with peers, industry trailblazers, and talent pipeline experts.
Agenda Highlights:
  • IBRI Internship Experience: Successes and lessons from a leading internship program.
  • Future-Ready Workforce: Trends, data, and strategies to build resilient teams.
  • Fueling Talent Pipelines: How industry partnerships are shaping Indiana’s future workforce.
This is your opportunity to gain insights, build relationships, and equip your organization for sustained growth.
 

This event is Sold Out. 

Thank you to our sponsors for their continued support in helping provide engaging events that connect Indiana's life sciences community.

Presenting Sponsor

Innovation Sponsors

FrameWORX: March 13, 2025

Highlighting Innovation and Industry Growth
 

Indiana’s life sciences industry is at the forefront of innovation, transforming groundbreaking research into market-ready solutions. Join us for our next FrameWORX event as we explore how startups, research institutions, and industry leaders are driving discovery, commercialization, and economic growth in Indiana.

This session will showcase real-world success stories of entrepreneurs and organizations navigating the journey from R&D to commercialization, highlight the growing innovation ecosystem, and provide valuable networking opportunities with key players in life sciences and entrepreneurship.

Agenda

3-3:30 PM

Registration and Networking

Doors open at 3 p.m.

Please join us at your earliest convenience to enjoy our complimentary bar and networking ahead of the program.

3:30-5:00 PM

Start-Up Success and Synergizing Innovation

A strong innovation ecosystem is key to fostering research-driven economic growth. 

Indiana-based startups that are navigating the journey toward commercializing their research will share firsthand the challenges and milestones of their entrepreneurial journey. 

And, leaders from Indiana’s foremost academic and research institutions—including Indiana University, Purdue University, Notre Dame, and the Indiana Biosciences Research Institute—will come together to explore how collaborative strategies are accelerating the transformation of cuttingedge research into realworld solutions. 

Guest Speakers


Diana Caldwell
CEO, Amplified Sciences

Dr. Richard Church
Chief Growth and Strategy Officer, Parkview Health

Derek Small
Founder, Managing Director at Luson Bioventures

Guest Speakers

Paul Bohn
Director, Bioengineering and Life Sciences (BELS) Initiative, University of Notre Dame


Chia-Ying (James) Lin
Executive Director of Convergent Bioscience and Technology Institute

Alan Palkowitz
President and CEO, Indiana Biosciences Research Institute


David Rosenberg
Inaugural President & CEO, IU LAB


Dr. David Umulis
Senior Vice Provost for Indianapolis, Purdue University

5-5:30 PM

Post-Event Networking

Join us for refreshments and additional networking following the discussion. 

2025 FrameWORX Events

June 20: Workforce Resilience in Life Sciences

August 20: Warsaw, Indiana – The Orthopedic Capital of the World

December 4: Advancing Opportunities in Nuclear Medicine Manufacturing

Gaining Momentum: Highlighting Innovation and Collaboration in Indiana’s Life Sciences Hubs

Indiana’s regional life sciences and innovation hubs are spearheading groundbreaking advancements thanks to a collective focus and commitment. Key experts from across Indiana, including Warsaw, West Lafayette, and Bloomington, shared their insights into how their regions are fueling growth, and the importance of statewide and cross-sector collaboration to continue fostering innovation.

Leading by Example: Life Sciences Manufacturing in Indiana

Indiana stands as a leader in manufacturing, drawing envy from states nationwide. Our state leads the nation in pharmaceutical exports and holds the second place in exporting life sciences products. The path ahead is marked by significant opportunities, such as Lilly’s $9 billion manufacturing pledge in Boone County, our pioneering role in radiopharmaceutical manufacturing, and Ivy Tech’s recent unveiling of a 4,000-square-foot Biopharma Science and Technology Lab. These developments position Indiana at the forefront of potential growth, provided we maintain our focus and continue to drive forward with unwavering commitment.

Our Life Sciences Workforce: Success Fuels Success

Over the last century – and especially over the last two decades – Indiana has become synonymous with life sciences. Today, our state is home to more than 3,100 life sciences establishments, employing 67,000+ Hoosiers working to advance treatments for Alzheimer’s and obesity, state-of-the-art orthopedics, nuclear medicine, and manufacturing.

As more establishments look to Indiana for business opportunities – they’re also discovering a highly-skilled, capable workforce. And the best is yet to come – as demonstrated at our recent FrameWORX at 16 Tech. Indiana’s life sciences ecosystem came together for an engaging conversation about current efforts to expand our training and workforce pathways and talent pipeline.

Our recent federal Tech Hub designation will provide Indiana with a $51 million grant for developing workforce and training initiatives, governance, and bringing products to market, helping position Indiana as a global leader in biotech.

“It’s an incredible opportunity for Central Indiana,” said Melina Kennedy, CEO of Central Indiana Corporate Partnership, during her discussion session. “We are focused on biomanufacturing as one of our four key pillars and will leverage our current strengths to grow this important sector in Indiana.”

The grant was made possible by the Regional Technology and Innovation Hubs program stemming from the CHIPS and Science Act of 2022. Heartland BioWorks was selected as one of only 12 Tech Hubs nationwide to receive funding to help drive improvements and expansion into the environment.

Ivy Tech recently opened a new biopharmaceutical science and technology lab with more than 4,000 square feet of equipment and technology that simulates the working environment of biotechnology manufacturing facilities, demonstrating how this could work.

The facility is located roughly ten minutes from Eli Lilly and Company’s Indianapolis manufacturing facility, which has supported the project and has a vested interest in its success.

And at Purdue – which recently launched its new Indianapolis campus – leaders are continuing to focus on helping Indiana meet the manufacturing needs of the broader life sciences industry.

The approach is working. Wade Franchville, founder and managing director of Harba Solutions, Inc., said Indiana’s labor market is “booming” and that his team alone is recruiting about 170 open life sciences positions across the Hoosier state.

And with the endless competition for talent in mind, he reminded the FrameWORX audience: “Boston researches things; Indiana makes things.” The tech hub grant and designation will help build upon that legacy.

Presenting Sponsor:

A Glimpse into the Future of Nuclear Medicine

Our FrameWORX series this year has been a fascinating journey through the pillars of our 10-year Strategy for Indiana’s life sciences sector. Our final event of the year – held in early December at the Indiana Biosciences Research Institute – can feel like a big gulp of science. But no area captures Indiana’s life sciences growth like nuclear medicine.

Indiana leads the nation in conventional pharmaceutical exports, and at least 14 life sciences companies today are developing and manufacturing radiopharmaceuticals – propped by our state’s central location and logistics expertise. Decades of life sciences leadership are complemented by the logistics required to produce treatments and diagnostics that leave little room for shelf life. Radioactive materials degrade quickly, and each dose must reach the intended patient within 3 to 5 days from production. Indiana’s FedEx hub, the second largest in the world, is a major advantage – as is the fact Central Indiana is a 12-hour drive from approximately half the U.S.

Nuclear medicine is revolutionizing the way we diagnose and treat diseases, offering innovative solutions that are improving patient outcomes and pushing the boundaries of modern healthcare. Indiana, with its renowned research institutions and strategic partnerships, is at the forefront of this movement. Additionally, Indiana’s central location, combined with its robust transportation infrastructure, positions the state as an ideal hub for the production and delivery of these critical therapies.

Indiana is on the leading edge of a booming technology. Nuclear medicine is a $6 billion industry in the U.S. and is expected to triple in the next 7 years. Heartland BioWorks, designated a regional technology and innovation hub by the federal Economic Development Administration, has established BioTrain, an institute designed to prepare talent for entry-level biomanufacturing roles. BioTrain will be located at the 16 Tech Innovation District. And just north of Indianapolis, Purdue has the nation’s largest nuclear medicine pharmacy program in the country.

As demonstrated at our FrameWORX, radiopharmaceuticals are used in nuclear medicine imaging and procedures – particularly for prostate and other cancers. They are administered systemically, but their biomolecular properties cause them to localize in specific tissues. Years ago, doctor might use a sledgehammer approach to treatment – in other words, diagnose and treat a large swath of the body to address diseases that were challenging to pinpoint. Radiopharmaceuticals are more like using an arrow and bull’s eye. Precision leads to less invasiveness and more precise treatments for patients.

Researchers and business leaders from IU School of Medicine, Purdue, life sciences companies, and the patient advocacy world drove a robust discussion about the future of radiopharmaceuticals. Perhaps no one said it better than Geoff Towle, a vice president and senior general manager at Novartis. Geoff joined us from his New Jersey headquarters because his company has built a large radiopharmaceutical manufacturing plant in Indianapolis.

“This feels like reimagining medicine,” he said. “Nuclear medicine is incredibly effective and exquisitely targeted. Patients are waiting for this and that’s what we need to focus on.”